Evaluation of Superdisintigrants In Directly Compressible Albuterol Tablet
Nouf K. Alkahtani
Departmnet of pharmaceutics
King Saud University
Riyadh, Saudi Arabia
Abstract:
Disintegrants are agents added to tablet formulations to promote the break-up of the tablet into smaller fragments in an aqueous environment, thereby increasing the available surface area and promoting a more rapid release of the drug substance. In more recent years, several newer disintegrants have been developed, often called "super disintegrants." .The objective of this study was to formulate and evaluate the superdisintegrants for and simultaneous delivery of anti-asthmatic drug Salbutamol sulphate .which is often indicated for the management of asthma, their frequent dosing may reduce compliance, thus making prolonged release formulation necessary. The matrix tablets were prepared by direct compression method the three groups was classified according to the disintegrants added and each group was classified according to the concentration on disintegrants added. The three formulations are compactrol-starch , compactrol- crosspovidone and avicel- crosspovidone . The granules showed satisfactory flow properties and compressibility. All the 12 tablets formulations showed acceptable pharmacotechnical properties and complied with the in-house specifications for tested parameters. They are evaluated for angle of repose, friability, hardness, disintegration and dissolution, content uniformity and weight variation.
